Article
Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease.
Nature - 23 Apr 2009
Gu YuanYuan, Harley Isaac T W, Henderson Lindsay B, Aronow Bruce J, Vietor Ilja, Huber Lukas A, Harley John B, Kilpatrick Jeffrey R, Langefeld Carl D, Williams Adrienne H, Jegga Anil G, Chen Jing, Wills-Karp Marsha, Arshad S Hasan, Ewart Susan L, Thio Chloe L, Flick Leah M, Filippi Marie-Dominique, Grimes H Leighton, Drumm Mitchell L, Cutting Garry R, Knowles Michael R, Karp Christopher L
Abstract excerpt
Lung disease is the major cause of morbidity and mortality in cystic fibrosis, an autosomal recessive disease caused by mutations in CFTR. In cystic fibrosis, chronic infection and dysregulated neutrophilic inflammation lead to progressive airway destruction. The severity of cystic fibrosis lung disease has considerable heritability, independent of CFTR genotype. To identify genetic modifiers, here we performed a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.