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Article

The effect of BPIFA1/SPLUNC1 genetic variation on its expression and function in asthmatic airway epithelium

17 Apr 2019

Abstract excerpt

Bacterial permeability family member A1 (BPIFA1), also known as short palate, lung, and nasal epithelium clone 1 (SPLUNC1), is a protein involved in the antiinflammatory response. The goal of this study was to determine whether BPIFA1 expression in asthmatic airways is regulated by genetic variations, altering epithelial responses to type 2 cytokines (e.g., IL-13). Nasal epithelial cells from patients with mild...

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PMID: 30996135
DOI: 10.1172/jci.insight.127237

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