Article
Identification of molecular signatures of cystic fibrosis disease status with plasma-based functional genomics.
Physiological genomics - 1 Jan 2019
Levy Hara, Jia Shuang, Pan Amy, Zhang Xi, Kaldunski Mary, Nugent Melodee L, Reske Melissa, Feliciano Rachel A, Quintero Diana, Renda Michael M, Woods Katherine J, Murkowski Kathy, Johnson Keven, Verbsky James, Dasu Trivikram, Ideozu Justin Eze, McColley Susanna, Quasney Michael W, Dahmer Mary K, Avner Ellis, Farrell Philip M, Cannon Carolyn L, Jacob Howard, Simpson Pippa M, Hessner Martin J
Abstract excerpt
Although cystic fibrosis (CF) is attributed to dysfunction of a single gene, the relationships between the abnormal gene product and the development of inflammation and progression of lung disease are not fully understood, which limits our ability to predict an individual patient's clinical course and treatment response. To better understand CF progression, we characterized the molecular signatures of CF disease...
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