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Article

Sirtuin 1 activator <scp>SRT</scp>2104 protects Huntington's disease mice

31 Oct 2014

Abstract excerpt

Sirtuin 1 is a nicotinamide adenine dinucleotide-dependent protein deacetylase which regulates longevity and improves metabolism. Activation of Sirtuin 1 confers beneficial effects in models of neurodegenerative diseases. We and others have provided convincing evidence that overexpression of Sirtuin 1 plays a neuroprotective role in mouse models of Huntington's disease. In this study, we report that SRT2104, a...

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PMID: 25574479
DOI: 10.1002/acn3.135

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