Article

Biphasic JNK–Erk Signaling Separates Induction and Maintenance of Cell Senescence after DNA Damage

2022-06-16

Abstract excerpt

<h4>SUMMARY</h4> Genotoxic stress in mammalian cells, including that caused by anti-cancer chemotherapy, can induce temporary cell cycle arrest, DNA damage-induced senescence (DDIS) or apoptotic cell death. Despite obvious clinical importance, it is unclear how the signals emerging from DNA damage are integrated together with other cellular signaling pathways monitoring the cell’s environment and/or internal stat...

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Literature Corpus work: 4a65b057-0bab-54e1-87e5-e53a7f436e5b
DOI: 10.1101/2022.06.15.496288

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