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Article

Genomic variants associated with primary biliary cirrhosis

1 Jan 2010

Abstract excerpt

Primary biliary cirrhosis (PBC) is an autoimmune hepatobiliary disease characterized by immune-mediated injury of small and medium-sized bile ducts, eventually leading to liver cirrhosis. Several studies have addressed PBC immunopathology, and the data support an immune activation leading to autoantibodies and autoreactive T cells acting against the lipoylated 2-oxoacid dehydrogenase complexes. The causes of the...

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PMID: 20193050
DOI: 10.1186/gm126

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