Article
The alpha/beta sheath and its cytoplasmic tyrosines are required for signaling by the B-cell antigen receptor but not for capping or for serine/threonine-kinase recruitment.
Proceedings of the National Academy of Sciences of the United States of America - 18 Jan 1994
Williams G T, Peaker C J, Patel K J, Neuberger M S
Abstract excerpt
The B-cell antigen receptor is composed of membrane immunoglobulin sheathed by an alpha/beta heterodimer. The complex is noncovalently associated with protein kinase activity, and crosslinking of the receptor leads to capping and transmembrane signaling. Here we show that the sheath is not necessary either for this capping or for the association of membrane immunoglobulin with the detergent-insoluble cytoskeletal...
Topics
- Amino Acid Sequence
- Animals
- Cell Line
- Cross-Linking Reagents
- Cytoplasm
- Immunologic Capping
- Mice
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Protein Conformation
- Protein Serine-Threonine Kinases
- Receptors, Antigen, B-Cell