Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In vivo cytotoxicity of type I CD20 antibodies critically depends on Fc receptor ITAM signaling.

Cancer research - 15 Apr 2010

de Haij Simone, Jansen J H Marco, Boross Peter, Beurskens Frank J, Bakema Jantine E, Bos Desiree L, Martens Anton, Verbeek J Sjef, Parren Paul W H I, van de Winkel Jan G J, Leusen Jeanette H W

Abstract excerpt

Antibody-Fc receptor (FcR) interactions play an important role in the mechanism of action of most therapeutic antibodies against cancer. Effector cell activation through FcR triggering may induce tumor cell killing via antibody-dependent cellular cytotoxicity (ADCC). Reciprocally, FcR cross-linking of antibody may lead to the induction of apoptotic signaling in tumor cells. The relative importance of these...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immunotherapy
Share to Antibodies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Antibodies, Monoclonal, Humanized

Share to Antibodies, Monoclonal, Murine-Derived

Share to Antigens, CD20

Share to Melanoma, Experimental

Share to Receptors, Fc

Share to Rituximab

Source

Identifiers

PMID: 20354182
DOI: 10.1158/0008-5472.CAN-09-4109

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In vivo cytotoxicity of type I CD20 antibodies critically depends on Fc receptor ITAM signaling.PMID 20354182Read ↗

An Fcγ receptor-dependent mechanism drives antibody-mediated target-receptor signaling in cancer cells.Semantic proximity Read ↗

The in vivo mechanism of action of CD20 monoclonal antibodies depends on local tumor burdenSemantic proximity Read ↗

Fc-Receptor Interactions Regulate Both Cytotoxic and Immunomodulatory Therapeutic Antibody Effector FunctionsSemantic proximity Read ↗

Molecular engineering to improve antibodies' anti-lymphoma activity.Semantic proximity Read ↗

A novel, native-format bispecific antibody triggering T-cell killing of B-cells is robustly active in mouse tumor models and cynomolgus monkeys.Semantic proximity Read ↗

Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin lymphomasSemantic proximity Read ↗

Enhanced binding affinity for FcgammaRIIIa of fucose-negative antibody is sufficient to induce maximal antibody-dependent cellular cytotoxicity.Semantic proximity Read ↗

Inhibitory Fcγ receptor engagement drives adjuvant and anti-tumor activities of agonistic CD40 antibodies.Semantic proximity Read ↗

Isotype selection for antibody-based cancer therapySemantic proximity Read ↗

Asymmetrical Fc engineering greatly enhances antibody-dependent cellular cytotoxicity (ADCC) effector function and stability of the modified antibodies.Semantic proximity Read ↗

Neutralizing IFNγ improves safety without compromising efficacy of CAR-T cell therapy in B-cell malignanciesSemantic proximity Read ↗

Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.