Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FcR-like 2 Inhibition of B cell receptor-mediated activation of B cells.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2010

Jackson Tanisha A, Haga Christopher L, Ehrhardt Götz R A, Davis Randall S, Cooper Max D

Abstract excerpt

FcR-like (FCRL) 2 is a transmembrane protein with immunomodulatory potential that is preferentially expressed by memory B cells in humans. It has two consensus ITIMs in addition to a putative ITAM sequence in its cytoplasmic domain. We have confirmed the cellular distribution of FCRL2 and analyzed its functional potential to show that coligation with the BCR leads to tyrosine phosphorylation of its ITIM motifs...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Amino Acid Substitution

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to B-Lymphocytes

Share to Immunologic Memory

Share to Lymphocyte Activation

Share to Phosphorylation

Share to Receptors, Antigen, B-Cell

Share to Receptors, Cell Surface

Source

Open in PubMed Open full text

Identifiers

PMID: 21068405
DOI: 10.4049/jimmunol.1002305
PMCID: PMC5381824

Genes

BCR
FCRL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FcR-like 2 Inhibition of B cell receptor-mediated activation of B cells.PMID 21068405Read ↗

FCRL1 immunoregulation in B cell development and malignancySemantic proximity Read ↗

The inhibitory potential of Fc receptor homolog 4 on memory B cells.Semantic proximity Read ↗

Fc Receptor-Like MoleculesSemantic proximity Read ↗

Update on Fc receptor-like (FCRL) family: new immunoregulatory players in health and diseasesSemantic proximity Read ↗

Fc Receptor-Like A Associates with Intracellular IgG and IgM but Is Dispensable for Antigen-Specific Immune ResponsesSemantic proximity Read ↗

Understanding Fc Receptor Involvement in Inflammatory Diseases: From Mechanisms to New Therapeutic ToolsSemantic proximity Read ↗

IgG Fc ReceptorsSemantic proximity Read ↗

Fc Receptors and Their Role in Immune Regulation and AutoimmunitySemantic proximity Read ↗

Expression profile of FcgammaRIIb on leukocytes and its dysregulation in systemic lupus erythematosus.Semantic proximity Read ↗

Fc Receptor–like 5 Expression Distinguishes Two Distinct Subsets of Human Circulating Tissue–like Memory B CellsSemantic proximity Read ↗

Characterization of human FCRL4-positive B cells.Semantic proximity Read ↗

The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.