Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An Fcγ receptor-dependent mechanism drives antibody-mediated target-receptor signaling in cancer cells.

Cancer cell - 18 Jan 2011

Wilson Nicholas S, Yang Becky, Yang Annie, Loeser Stefanie, Marsters Scot, Lawrence David, Li Yun, Pitti Robert, Totpal Klara, Yee Sharon, Ross Sarajane, Vernes Jean-Michel, Lu Yanmei, Adams Cam, Offringa Rienk, Kelley Bob, Hymowitz Sarah, Daniel Dylan, Meng Gloria, Ashkenazi Avi

Abstract excerpt

Antibodies to cell-surface antigens trigger activatory Fcγ receptor (FcγR)-mediated retrograde signals in leukocytes to control immune effector functions. Here, we uncover an FcγR mechanism that drives antibody-dependent forward signaling in target cells. Agonistic antibodies to death receptor 5 (DR5) induce cancer-cell apoptosis and are in clinical trials; however, their mechanism of action in vivo is not fully...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Monoclonal, Humanized
Share to CD40 Antigens

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HCT116 Cells

Share to Immunoglobulin Fc Fragments

Share to Leukocytes

Share to Myeloid Cells

Share to Receptors, IgG

Share to Receptors, TNF-Related Apoptosis-Inducing Ligand

Source

Identifiers

PMID: 21251615
DOI: 10.1016/j.ccr.2010.11.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An Fcγ receptor-dependent mechanism drives antibody-mediated target-receptor signaling in cancer cells.PMID 21251615Read ↗

Fc-Receptor Interactions Regulate Both Cytotoxic and Immunomodulatory Therapeutic Antibody Effector FunctionsSemantic proximity Read ↗

In vivo cytotoxicity of type I CD20 antibodies critically depends on Fc receptor ITAM signaling.Semantic proximity Read ↗

Antibody Fc: Linking Adaptive and Innate ImmunitySemantic proximity Read ↗

Reimagining antibody-dependent cellular cytotoxicity in cancer: the potential of natural killer cell engagersSemantic proximity Read ↗

Inhibitory Fcγ receptor engagement drives adjuvant and anti-tumor activities of agonistic CD40 antibodies.Semantic proximity Read ↗

Update on Fc receptor-like (FCRL) family: new immunoregulatory players in health and diseasesSemantic proximity Read ↗

Human IgG2 Antibodies against Epidermal Growth Factor Receptor Effectively Trigger Antibody-Dependent Cellular Cytotoxicity but, in Contrast to IgG1, Only by Cells of Myeloid LineageSemantic proximity Read ↗

A CHIMERIC RECEPTOR ENABLING ANTIBODY-GUIDED RETARGETING OF CAR T- CELLSSemantic proximity Read ↗

Potent and selective antitumor activity of a T cell-engaging bispecific antibody targeting a membrane-proximal epitope of ROR1Semantic proximity Read ↗

TAM receptors in apoptotic cell clearance, autoimmunity, and cancerSemantic proximity Read ↗

No receptor stands alone: IgG B-cell receptor intrinsic and extrinsic mechanisms contribute to antibody memorySemantic proximity Read ↗

Effector mechanisms of therapeutic antibodies against ErbB receptors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.