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Article

Fc Binding by FcγRIIa Is Essential for Cellular Activation by the Anti-FcγRIIa mAbs 8.26 and 8.2.

Frontiers in immunology - 1 Jan 2021

Wines Bruce D, Trist Halina M, Esparon Sandra, Impey Rachael E, Mackay Graham A, Andrews Robert K, Soares da Costa Tatiana P, Pietersz Geoffrey A, Baker Ross I, Hogarth P Mark

Abstract excerpt

FcγR activity underpins the role of antibodies in both protective immunity and auto-immunity and importantly, the therapeutic activity of many monoclonal antibody therapies. Some monoclonal anti-FcγR antibodies activate their receptors, but the properties required for cell activation are not well defined. Here we examined activation of the most widely expressed human FcγR; FcγRIIa, by two non-blocking, mAbs, 8.26...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34759915
DOI: 10.3389/fimmu.2021.666813
PMCID: PMC8573391

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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