Article
EFF-1-mediated regenerative axonal fusion requires components of the apoptotic pathway.
Nature - 8 Jan 2015
Neumann Brent, Coakley Sean, Giordano-Santini Rosina, Linton Casey, Lee Eui Seung, Nakagawa Akihisa, Xue Ding, Hilliard Massimo A
Abstract excerpt
Functional regeneration after nervous system injury requires transected axons to reconnect with their original target tissue. Axonal fusion, a spontaneous regenerative mechanism identified in several species, provides an efficient means of achieving target reconnection as a regrowing axon is able to contact and fuse with its own separated axon fragment, thereby re-establishing the original axonal tract. Here we...
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