The fusogen AFF-1 can rejuvenate the regenerative potential of adult dendritic trees by self-fusion.

doi:10.1242/dev.150037

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Article

The fusogen AFF-1 can rejuvenate the regenerative potential of adult dendritic trees by self-fusion.

Development (Cambridge, England) - 1 Jul 2017

Kravtsov Veronika, Oren-Suissa Meital, Podbilewicz Benjamin

Abstract excerpt

The aging brain undergoes structural changes that affect brain homeostasis, neuronal function and consequently cognition. The complex architecture of dendritic arbors poses a challenge to understanding age-dependent morphological alterations, behavioral plasticity and remodeling following brain injury. Here, we use the PVD polymodal neurons of C. elegans as a model to study how aging affects neuronal plasticity....

Topics

Aging
Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Cell Fusion
Dendrites
Insulin
Insulin-Like Growth Factor I
Larva
Models, Biological
Mutation
Regeneration
Signal Transduction

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Open in PubMed

Identifiers

PMID: 28576774
DOI: 10.1242/dev.150037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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