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Article

Methylome analysis for spina bifida shows SOX18 hypomethylation as a risk factor with evidence for a complex (epi)genetic interplay to affect neural tube development.

Clinical epigenetics - 1 Jan 2016

Rochtus Anne, Winand Raf, Laenen Griet, Vangeel Elise, Izzi Benedetta, Wittevrongel Christine, Moreau Yves, Verpoorten Carla, Jansen Katrien, Van Geet Chris, Freson Kathleen

Abstract excerpt

BACKGROUND: Neural tube defects (NTDs) are severe congenital malformations that arise from failure of neurulation during early embryonic development. The molecular basis underlying most human NTDs still remains largely unknown. Based on the hypothesis that folic acid prevents NTDs by stimulating methylation reactions, DNA methylation changes could play a role in NTDs. We performed a methylome analysis for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27757173
DOI: 10.1186/s13148-016-0272-8
PMCID: PMC5064967

Genes

SOX18
ABAT
BMP4
CNTNAP1
HOXB7
SNED1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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