Article

A Multi-Omics Atlas of Naturally Occurring Myelomeningocele in a Large-Animal Model Reveals Heritable Architecture

2026-05-13

Abstract excerpt

Neural tube closure relies on tightly coordinated morphogenetic programs integrating convergent extension, apical constriction of the neuroepithelium, and precise cell-cell interactions across germ layers. Disruption of these processes results in myelomeningocele, a severe complex congenital defect with lifelong multisystem consequences whose genetic and epigenetic determinants remain poorly defined. Using a sheep...

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Literature Corpus work: d4a84eed-94d5-5c0a-a40a-8c918601113c
DOI: 10.64898/2026.05.12.724696

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