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Article

A hinge migration mechanism unlocks the evolution of green-to-red photoconversion in GFP-like proteins.

Structure (London, England : 1993) - 6 Jan 2015

Kim Hanseong, Zou Taisong, Modi Chintan, Dörner Katerina, Grunkemeyer Timothy J, Chen Liqing, Fromme Raimund, Matz Mikhail V, Ozkan S Banu, Wachter Rebekka M

Abstract excerpt

In proteins, functional divergence involves mutations that modify structure and dynamics. Here we provide experimental evidence for an evolutionary mechanism driven solely by long-range dynamic motions without significant backbone adjustments, catalytic group rearrangements, or changes in subunit assembly. Crystallographic structures were determined for several reconstructed ancestral proteins belonging to a GFP...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25565105
DOI: 10.1016/j.str.2014.11.011
PMCID: PMC4370283

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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