Unraveling the Mechanism of a LOV Domain Optogenetic Sensor: A Glutamine Lever Induces Unfolding of the Jα Helix.

doi:10.1021/acschembio.0c00543

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Article

Unraveling the Mechanism of a LOV Domain Optogenetic Sensor: A Glutamine Lever Induces Unfolding of the Jα Helix.

ACS chemical biology - 16 Oct 2020

Iuliano James N, Collado Jinnette Tolentino, Gil Agnieszka A, Ravindran Pavithran T, Lukacs Andras, Shin SeungYoun, Woroniecka Helena A, Adamczyk Katrin, Aramini James M, Edupuganti Uthama R, Hall Christopher R, Greetham Gregory M, Sazanovich Igor V, Clark Ian P, Daryaee Taraneh, Toettcher Jared E, French Jarrod B, Gardner Kevin H, Simmerling Carlos L, Meech Stephen R, Tonge Peter J

Abstract excerpt

Light-activated protein domains provide a convenient, modular, and genetically encodable sensor for optogenetics and optobiology. Although these domains have now been deployed in numerous systems, the precise mechanism of photoactivation and the accompanying structural dynamics that modulate output domain activity remain to be fully elucidated. In the C-terminal light-oxygen-voltage (LOV) domain of plant...

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PMID: 32880430
DOI: 10.1021/acschembio.0c00543
PMCID: PMC7572778

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