Article
Probing the allostery in dimeric near-infrared biomarkers derived from the bacterial phytochromes: The impact of the T204A substitution on the inter-monomer interaction.
International journal of biological macromolecules - 1 Nov 2020
Stepanenko Olesya V, Stepanenko Olga V, Turoverov Konstantin K, Kuznetsova Irina M
Abstract excerpt
In dimeric near-infrared (NIR) biomarkers engineered from bacterial phytochromes the covalent binding of BV to the cysteine residue in one monomer of a protein allosterically prevents the chromophore embedded into the pocket of the other monomer from the covalent binding to the cysteine residue. In this work, we analyzed the impact on inter-monomeric allosteric effects in dimeric NIR biomarkers of substitutions...
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