Article
Mechanism-based tuning of a LOV domain photoreceptor.
Nature chemical biology - 1 Nov 2009
Zoltowski Brian D, Vaccaro Brian, Crane Brian R
Abstract excerpt
Phototropin-like LOV domains form a cysteinyl-flavin adduct in response to blue light but show considerable variation in output signal and the lifetime of the photo-adduct signaling state. Mechanistic studies of the slow-cycling fungal LOV photoreceptor Vivid (VVD) reveal the importance of reactive cysteine conformation, flavin electronic environment and solvent accessibility for adduct scission and thermal...
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