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Article

Erythropoietin-driven signaling ameliorates the survival defect of DMT1-mutant erythroid progenitors and erythroblasts.

Haematologica - 1 Oct 2012

Horvathova Monika, Kapralova Katarina, Zidova Zuzana, Dolezal Dalibor, Pospisilova Dagmar, Divoky Vladimir

Abstract excerpt

BACKGROUND: Hypochromic microcytic anemia associated with ineffective erythropoiesis caused by recessive mutations in divalent metal transporter 1 (DMT1) can be improved with high-dose erythropoietin supplementation. The aim of this study was to characterize and compare erythropoiesis in samples from a DMT1-mutant patient before and after treatment with erythropoietin, as well as in a mouse model with a DMT1...

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Source

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Identifiers

PMID: 22580996
DOI: 10.3324/haematol.2011.059550
PMCID: PMC3487548

Genes

GDF15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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