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Article

Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneity

5 Jan 2015

Abstract excerpt

Glioblastoma (GBM) is a cancer comprised of morphologically, genetically, and phenotypically diverse cells. However, an understanding of the functional significance of intratumoral heterogeneity is lacking. We devised a method to isolate and functionally profile tumorigenic clones from patient glioblastoma samples. Individual clones demonstrated unique proliferation and differentiation abilities. Importantly,...

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PMID: 25561528
DOI: 10.1073/pnas.1320611111

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