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Article

A new model isolates glioblastoma clonal interactions and reveals unexpected modes for regulating motility, proliferation, and drug resistance.

Scientific reports - 22 Nov 2019

Davis Justin B, Krishna Sreshta S, Abi Jomaa Ryan, Duong Cindy T, Espina Virginia, Liotta Lance A, Mueller Claudius

Abstract excerpt

Tumor clonal heterogeneity drives treatment resistance. But robust models are lacking that permit eavesdropping on the basic interaction network of tumor clones. We developed an in vitro, functional model of clonal cooperation using U87MG glioblastoma cells, which isolates fundamental clonal interactions. In this model pre-labeled clones are co-cultured to track changes in their individual motility, growth, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31758030
DOI: 10.1038/s41598-019-53850-7
PMCID: PMC6874607

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