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Article

Restoration of progranulin expression rescues cortical neuron generation in an induced pluripotent stem cell model of frontotemporal dementia.

Stem cell reports - 13 Jan 2015

Raitano Susanna, Ordovàs Laura, De Muynck Louis, Guo Wenting, Espuny-Camacho Ira, Geraerts Martine, Khurana Satish, Vanuytsel Kim, Tóth Balazs I, Voets Thomas, Vandenberghe Rik, Cathomen Toni, Van Den Bosch Ludo, Vanderhaeghen Pierre, Van Damme Philip, Verfaillie Catherine M

Abstract excerpt

To understand how haploinsufficiency of progranulin (PGRN) causes frontotemporal dementia (FTD), we created induced pluripotent stem cells (iPSCs) from patients carrying the GRN(IVS1+5G > C) mutation (FTD-iPSCs). FTD-iPSCs were fated to cortical neurons, the cells most affected in FTD. Although g...

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Identifiers

PMID: 25556567
DOI: 10.1016/j.stemcr.2014.12.001
PMCID: PMC4297877

Genes

GRN
FOXP2
TBR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25556567-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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