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Article

Suberoylanilide hydroxamic acid increases progranulin production in iPSC-derived cortical neurons of frontotemporal dementia patients.

Neurobiology of aging - 1 Jun 2016

Almeida Sandra, Gao Fuying, Coppola Giovanni, Gao Fen-Biao

Abstract excerpt

Mutations in the granulin (GRN) gene cause frontotemporal dementia (FTD) due to progranulin haploinsufficiency. Compounds that can increase progranulin production and secretion may be considered as potential therapeutic drugs; however, very few of them have been directly tested on human cortical neurons. To this end, we differentiated 9 induced pluripotent stem cell lines derived from a control subject, a...

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Source

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Identifiers

PMID: 27143419
DOI: 10.1016/j.neurobiolaging.2016.03.001
PMCID: PMC8256425

Genes

GRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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