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Lineage tracing: The gold standard to claim direct reprogramming in vivo

4 Feb 2022

Abstract excerpt

The discovery that many types of fully differentiated somatic cells can be “reprogrammed” back to a pluripotent state through epigenetic modifications driven by specific transcription factors opened the door for cell alchemy. In theory, any cell could be switched from one fate to another, and it seems logical that a closer relationship between the cells would confer easier reprogramming.1 Astrocytes and neurons...

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PMID: 35123656
DOI: 10.1016/j.ymthe.2022.01.029

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