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Article

Genetic variation in NR1H4 encoding the bile acid receptor FXR determines fasting glucose and free fatty acid levels in humans.

The Journal of clinical endocrinology and metabolism - 1 Jul 2013

Heni Martin, Wagner Robert, Ketterer Caroline, Böhm Anja, Linder Katarzyna, Machicao Fausto, Machann Jürgen, Schick Fritz, Hennige Anita M, Stefan Norbert, Häring Hans-Ulrich, Fritsche Andreas, Staiger Harald

Abstract excerpt

CONTEXT: Bile acid signaling via farnesoid X receptor (FXR) regulates glucose and lipid levels, fat mass, and hepatic steatosis in animal models. OBJECTIVE: To understand the role of FXR in human metabolism, we investigated associations of common single-nucleotide polymorphisms (SNPs) in the FXR-encoding gene NR1H4 with glucose and lipid metabolism, body fat mass, and liver fat content. DESIGN: We genotyped 2166...

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PMID: 23640969
DOI: 10.1210/jc.2013-1177

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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