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Article

Altered DNA base excision repair profile in brain tissue and blood in Alzheimer’s disease

28 May 2016

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) is a progressive, multifactorial neurodegenerative disorder that is the main cause of dementia globally. AD is associated with increased oxidative stress, resulting from imbalance in production and clearance of reactive oxygen species (ROS). ROS can damage DNA and other macromolecules, leading to genome instability and disrupted cellular functions. Base excision repair (BER)...

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PMID: 27234294
DOI: 10.1186/s13041-016-0237-z

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