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Article

DNA base excision repair activities in mouse models of Alzheimer's disease.

Neurobiology of aging - 1 Dec 2009

Weissman Lior, de Souza-Pinto Nadja C, Mattson Mark P, Bohr Vilhelm A

Abstract excerpt

Alzheimer's disease (AD) has been correlated with elevated levels of oxidative DNA damage. Base excision repair (BER) is the main repair pathway for the removal of oxidative DNA base modifications. We have recently found significant functional deficiencies in BER in brains of sporadic AD and amnestic mild cognitive impairment patients. In this study we tested whether altered BER activities are associated with...

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PMID: 18378358
DOI: 10.1016/j.neurobiolaging.2008.02.014
PMCID: PMC2763940

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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