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Secondary and therapy-related acute myeloid leukemias: Overlapping features, distinct trajectories.

Seminars in hematology - 1 Jun 2025

Guarnera Luca, Fabiani Emiliano, Silvestrini Giorgia, Attardi Enrico, Voso Maria Teresa

Abstract excerpt

Therapy-related acute myeloid leukemia (tAML) and AML arising from previous hematologic disorders (secondary AML, sAML) share similar biological features, including karyotype abnormalities and gene specific mutations, patient-related risk factors. Older age and lower performance status also contribute to dimal prognosis, and dismal prognosis, both in terms of response rate and overall survival. However, these 2...

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PMID: 40713190
DOI: 10.1053/j.seminhematol.2025.06.005

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