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Article

Human blood dendritic cell antigen 3 (BDCA3)(+) dendritic cells are a potent producer of interferon-λ in response to hepatitis C virus.

Hepatology (Baltimore, Md.) - 1 May 2013

Yoshio Sachiyo, Kanto Tatsuya, Kuroda Shoko, Matsubara Tokuhiro, Higashitani Koyo, Kakita Naruyasu, Ishida Hisashi, Hiramatsu Naoki, Nagano Hiroaki, Sugiyama Masaya, Murata Kazumoto, Fukuhara Takasuke, Matsuura Yoshiharu, Hayashi Norio, Mizokami Masashi, Takehara Tetsuo

Abstract excerpt

UNLABELLED: The polymorphisms in the interleukin (IL)-28B (interferon-lambda [IFN]-λ3) gene are strongly associated with the efficacy of hepatitis C virus (HCV) clearance. Dendritic cells (DCs) sense HCV and produce IFNs, thereby playing some cooperative roles with HCV-infected hepatocytes in the induction of interferon-stimulated genes (ISGs). Blood dendritic cell antigen 3 (BDCA3)(+) DCs were discovered as a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23213063
DOI: 10.1002/hep.26182

Genes

TLR3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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