Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nuclease activity of Legionella pneumophila Cas2 promotes intracellular infection of amoebal host cells.

Infection and immunity - 1 Mar 2015

Gunderson Felizza F, Mallama Celeste A, Fairbairn Stephanie G, Cianciotto Nicholas P

Abstract excerpt

Legionella pneumophila, the primary agent of Legionnaires' disease, flourishes in both natural and man-made environments by growing in a wide variety of aquatic amoebae. Recently, we determined that the Cas2 protein of L. pneumophila promotes intracellular infection of Acanthamoeba castellanii and Hartmannella vermiformis, the two amoebae most commonly linked to cases of disease. The Cas2 family of proteins is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Proteins
Share to Chromosomes, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Deoxyribonucleases

Share to Gene Expression Regulation, Bacterial

Share to Genetic Loci

Share to Host Specificity

Share to Legionella pneumophila

Share to Ribonucleases

Source

Open in PubMed Open full text

Identifiers

PMID: 25547789
DOI: 10.1128/IAI.03102-14
PMCID: PMC4333442

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nuclease activity of Legionella pneumophila Cas2 promotes intracellular infection of amoebal host cells.PMID 25547789Read ↗

Dual nuclease activity of a Cas2 protein in CRISPR –Cas subtype I‐B of Leptospira interrogansSemantic proximity Read ↗

<i>Legionella pneumophila</i> CRISPR-Cas suggests recurrent encounters with <i>Gokushovirinae</i>Semantic proximity Read ↗

The CRISPR ancillary effector Can2 is a dual-specificity nuclease potentiating type III CRISPR defenceSemantic proximity Read ↗

A type III-A CRISPR-Cas system employs degradosome nucleases to ensure robust immunitySemantic proximity Read ↗

CRISPR-prime editing, a versatile genetic tool to create specific mutations with a single nucleotide resolution in Leptospira.Semantic proximity Read ↗

The ribonuclease activity of Csm6 is required for anti-plasmid immunity by Type III-A CRISPR-Cas systems.Semantic proximity Read ↗

CRISPR-Cas12a targeting of ssDNA plays no detectable role in immunitySemantic proximity Read ↗

M. tuberculosis CRISPR/Cas proteins are secreted virulence factors that trigger cellular immune responsesSemantic proximity Read ↗

MtvS1 and MtvS2 Interact with RNA Polymerase to Regulate the <i>Francisella</i> Type V-A CRISPR-Cas SystemSemantic proximity Read ↗

CRISPR-Cas: an efficient tool for genome engineering of virulent bacteriophages.Semantic proximity Read ↗

Bioinformatic Identification of CRISPR-Cas Systems in <em>Leptospira</em>: An Update on Their Distribution Across 77 SpeciesSemantic proximity Read ↗

CRISPR/Cas9 gene editing in the heterotrophic protist <i>Acanthamoeba castellanii</i>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.