Back to search

Article

Bioinformatic Identification of CRISPR-Cas Systems in <em>Leptospira</em>: An Update on Their Distribution Across 77 Species

2025-09-12

Abstract excerpt

Leptospirosis is a globally distributed zoonotic disease caused by pathogenic bacteria of the Leptospira genus. Genome editing in Leptospira has been difficult to perform. Currently, the functionality of the CRISPR-Cas system has been demonstrated in species such as Leptospira interrogans. However, the different CRISPR-Cas systems present in most of the 77 species are unknown. Therefore, the objective of this stud...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
2781af41-89fe-5453-9509-2d07e6b76a5d
DOI
10.20944/preprints202509.1116.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Bioinformatic Identification of CRISPR-Cas Systems in <em>Leptospira</em>: An Update on Their Distribution Across 77 SpeciesDOI 10.20944/preprints202509.1116.v1
Whole genome sequencing and de novo assembly of three virulent Indian isolates of Leptospira.Semantic proximity
Comparative analysis of whole genome sequences of <i>Leptospira</i> spp. from RefSeq database provide interspecific divergence and repertoire of virulence factorsSemantic proximity
CRISPR-prime editing, a versatile genetic tool to create specific mutations with a single nucleotide resolution in Leptospira.Semantic proximity
Dual nuclease activity of a Cas2 protein in CRISPR –Cas subtype I‐B of Leptospira interrogansSemantic proximity
<i>Legionella pneumophila</i> CRISPR-Cas suggests recurrent encounters with <i>Gokushovirinae</i>Semantic proximity
Description of the structural and functional genomic composition of <i>L. santarosai</i> serovar AliceSemantic proximity
Genetic manipulation of pathogenic Leptospira: CRISPR interference (CRISPRi)-mediated gene silencing and rapid mutant recovery at 37 °C.Semantic proximity
Induced protein expression in Leptospira spp. and its application to CRISPR/Cas9 mutant generation.Semantic proximity
Exploring Leptospira Interrogans FDAARGOS_203: Insights into AMR and Anti-phage DefenseSemantic proximity
Comparative genomic analysis of a Colombian strain of <i>Leptospira santarosai</i> serogroup Autumnalis serovar Alice and inference of its virulence factorsSemantic proximity
Genome features of Leptospira interrogans serovar CopenhageniSemantic proximity
The combination of RPA-CRISPR/Cas12a and Leptospira IgM RDT enhances the early detection of leptospirosisSemantic proximity
Select a neighboring publication to make it the new centre.