Increased number of multi-oocyte follicles (MOFs) in juvenile p27Kip1 mutant mice: potential role of granulosa cells.

doi:10.1093/humrep/des436

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Article

Increased number of multi-oocyte follicles (MOFs) in juvenile p27Kip1 mutant mice: potential role of granulosa cells.

Human reproduction (Oxford, England) - 1 Apr 2013

Pérez-Sanz J, Arluzea J, Matorras R, González-Santiago N, Bilbao J, Yeh N, Barlas A, Romin Y, Manova-Todorova K, Koff A, de la Hoz C

Abstract excerpt

STUDY QUESTION: Why are female mice that lack a functional p27 protein infertile? SUMMARY ANSWER: The absence of a functional p27 leads to a dramatic increase in the number of multi-oocyte follicles (MOFs) in juvenile female mice; p27 would promote the individualization of follicles favoring the development of fertile eggs. WHAT IS KNOWN ALREADY: p27-/- female mice are infertile. p27 suppresses excessive...

Topics

Animals
Cyclin-Dependent Kinase Inhibitor p27
Female
Granulosa Cells
Immunohistochemistry
Infertility
Mice
Mutation
Ovarian Follicle
Sexual Maturation

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Identifiers

PMID: 23300200
DOI: 10.1093/humrep/des436
PMCID: PMC4439520

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