Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased number of multi-oocyte follicles (MOFs) in juvenile p27Kip1 mutant mice: potential role of granulosa cells.

Human reproduction (Oxford, England) - 1 Apr 2013

Pérez-Sanz J, Arluzea J, Matorras R, González-Santiago N, Bilbao J, Yeh N, Barlas A, Romin Y, Manova-Todorova K, Koff A, de la Hoz C

Abstract excerpt

STUDY QUESTION: Why are female mice that lack a functional p27 protein infertile? SUMMARY ANSWER: The absence of a functional p27 leads to a dramatic increase in the number of multi-oocyte follicles (MOFs) in juvenile female mice; p27 would promote the individualization of follicles favoring the development of fertile eggs. WHAT IS KNOWN ALREADY: p27-/- female mice are infertile. p27 suppresses excessive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclin-Dependent Kinase Inhibitor p27
Share to Granulosa Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunohistochemistry

Share to Infertility

Share to Mutation

Share to Ovarian Follicle

Share to Sexual Maturation

Source

Open in PubMed Open full text

Identifiers

PMID: 23300200
DOI: 10.1093/humrep/des436
PMCID: PMC4439520

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased number of multi-oocyte follicles (MOFs) in juvenile p27Kip1 mutant mice: potential role of granulosa cells.PMID 23300200Read ↗

Asynchronous embryonic germ cell development leads to a heterogeneity of postnatal ovarian follicle activation and may influence the timing of puberty onset in miceSemantic proximity Read ↗

Cellular and molecular regulation of the activation of mammalian primordial follicles: somatic cells initiate follicle activation in adulthoodSemantic proximity Read ↗

The dynamics of the primordial follicle reserveSemantic proximity Read ↗

Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors.Semantic proximity Read ↗

Dysregulation of follicle development in a mouse model of premature ovarian insufficiency.Semantic proximity Read ↗

Oocyte-specific genes affect folliculogenesis, fertilization, and early development.Semantic proximity Read ↗

Kit signaling via PI3K promotes ovarian follicle maturation but is dispensable for primordial follicle activation.Semantic proximity Read ↗

Ovarian follicle development and transgenic mouse models.Semantic proximity Read ↗

Two classes of ovarian primordial follicles exhibit distinct developmental dynamics and physiological functionsSemantic proximity Read ↗

How Is the Number of Primordial Follicles in the Ovarian Reserve Established?1Semantic proximity Read ↗

Oocytes lacking O-glycans alter follicle development and increase fertility by increasing follicle FSH sensitivity, decreasing apoptosis, and modifying GDF9:BMP15 expression.Semantic proximity Read ↗

Impaired follicle development and infertility in female mice lacking steroidogenic factor 1 in ovarian granulosa cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.