Article

SMAD4 promotes somatic-germline contact during murine oocyte growth

2023-09-01

Abstract excerpt

Development of the mammalian oocyte requires physical contact with the surrounding granulosa cells of the follicle, which provide it with essential nutrients and regulatory signals. This contact is achieved through specialized filopodia, termed transzonal projections (TZPs), that extend from the granulosa cells to the oocyte surface. Transforming growth factor (TGFβ) family ligands produced by the oocyte increase...

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Literature Corpus work: 3f73a0a5-990d-5028-92fa-182d182e6dd7
DOI: 10.1101/2023.08.31.555753

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