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Article

Whole genome sequence analysis suggests intratumoral heterogeneity in dissemination of breast cancer to lymph nodes.

PloS one - 1 Jan 2014

Blighe Kevin, Kenny Laura, Patel Naina, Guttery David S, Page Karen, Gronau Julian H, Golshani Cyrus, Stebbing Justin, Coombes R Charles, Shaw Jacqueline A

Abstract excerpt

BACKGROUND: Intratumoral heterogeneity may help drive resistance to targeted therapies in cancer. In breast cancer, the presence of nodal metastases is a key indicator of poorer overall survival. The aim of this study was to identify somatic genetic alterations in early dissemination of breast ca...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25546409
DOI: 10.1371/journal.pone.0115346
PMCID: PMC4278903

Genes

CCNB2
TGIF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25546409-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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