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Article

Conformational dynamics of nonsynonymous variants at protein interfaces reveals disease association.

Proteins - 1 Mar 2015

Butler Brandon M, Gerek Z Nevin, Kumar Sudhir, Ozkan S Banu

Abstract excerpt

Recent studies have shown that the protein interface sites between individual monomeric units in biological assemblies are enriched in disease-associated non-synonymous single nucleotide variants (nsSNVs). To elucidate the mechanistic underpinning of this observation, we investigated the conforma...

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PMID: 25546381
DOI: 10.1002/prot.24748
PMCID: PMC4505818

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25546381-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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