Article
Detection of SRSF2-P95 mutation by high-resolution melting curve analysis and its effect on prognosis in myelodysplastic syndrome.
PloS one - 1 Jan 2014
Lin Jiang, Yang Jing, Wen Xiang-Mei, Yang Lei, Deng Zhao-Qun, Qian Zhen, Ma Ji-Chun, Guo Hong, Zhang Ying-Ying, Qian Wei, Qian Jun
Abstract excerpt
Hotspot mutations of serine/arginine-rich splicing factor 2 (SRSF2) gene have been identified in a proportion of hematologic malignancies including myelodysplastic syndrome (MDS). The aim of the present study was to develop a new approach to screen SRSF2 mutation and analyze the clinical relevance of SRSF2 mutations in Chinese MDS. A protocol based on high-resolution melting analysis (HRMA) was established to...
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