Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Development of a high-resolution melting curve analysis screening test for SRSF2 splicing factor gene mutations in myelodysplastic syndromes.

The Journal of molecular diagnostics : JMD - 1 Jan 2015

Garza Eduardo, Fabiani Emiliano, Noguera Nelida, Panetta Paola, Piredda Maria L, Borgia Loredana, Maurillo Luca, Catalano Gianfranco, Voso Maria T, Lo-Coco Francesco

Abstract excerpt

Somatic mutations of the spliceosome machinery have been recently identified by whole genome analysis in hematologic diseases, such as myelodysplastic syndrome, chronic lymphocytic leukemia, myeloproliferative neoplasms, acute myeloid leukemia, and advanced forms of mastocytosis, and also in nonhematologic conditions. SRSF2 is a member of the serine/arginine-rich family pre-mRNA splicing factors that plays a role...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Algorithms
Share to Bone Marrow

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myelodysplastic Syndromes

Share to Nucleic Acid Denaturation

Share to Ribonucleoproteins

Share to RNA Splicing

Share to Sensitivity and Specificity

Share to Serine-Arginine Splicing Factors

Source

Identifiers

PMID: 25445211
DOI: 10.1016/j.jmoldx.2014.08.002

Genes

SRSF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Development of a high-resolution melting curve analysis screening test for SRSF2 splicing factor gene mutations in myelodysplastic syndromes.PMID 25445211Read ↗

Detection of SRSF2-P95 mutation by high-resolution melting curve analysis and its effect on prognosis in myelodysplastic syndrome.Semantic proximity Read ↗

Development of a high-resolution melting analysis for the detection of the SF3B1 mutations.Semantic proximity Read ↗

Comparison of high-resolution melting analysis with direct sequencing for the detection of recurrent mutations in DNA methyltransferase 3A and isocitrate dehydrogenase 1 and 2 genes in acute myeloid leukemia patients.Semantic proximity Read ↗

Rapid detection of SMARCB1 sequence variation using high resolution melting.Semantic proximity Read ↗

High-resolution DNA melting analysis in clinical research and diagnostics.Semantic proximity Read ↗

SETBP1 mutations in Chinese patients with acute myeloid leukemia and myelodysplastic syndrome.Semantic proximity Read ↗

Rapid detection of KIT mutations in core-binding factor acute myeloid leukemia using high-resolution melting analysis.Semantic proximity Read ↗

High-Resolution Melting Curve Analysis as a Tool for Detection of SEC23B Gene Mutation Causing Congenital Dyserythropoietic Anemia Type II in Indian populationSemantic proximity Read ↗

Evaluation and characterization of a high-resolution melting analysis kit for rapid carrier-screening test of spinal muscular atrophy.Semantic proximity Read ↗

High-resolution melting analysis (HRMA): more than just sequence variant screening.Semantic proximity Read ↗

Diagnostic testing for IDH1 and IDH2 variants in acute myeloid leukemia an algorithmic approach using high-resolution melting curve analysis.Semantic proximity Read ↗

Comparison of high-resolution melting analysis with direct sequencing for detection of FLT3-TKD, FLT3-ITD and WT1 mutations in acute myeloid leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.