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SETBP1 mutations in Chinese patients with acute myeloid leukemia and myelodysplastic syndrome.

Pathology, research and practice - 1 May 2018

Yao Xin-Yu, Zhou Jing-Dong, Yang Jing, Zhang Wei, Ma Ji-Chun, Wen Xiang-Mei, Yao Dong-Ming, Xu Zi-Jun, Wu De-Hong, He Pin-Fang, Qian Jun, Lin Jiang

Abstract excerpt

BACKGROUND: Somatic mutations in SETBP1 gene have recently been detected in hematologic malignancies. The present study aimed to explore the frequency and clinical correlations of SETBP1 mutations in patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). METHODS: In this study, we used high-resolution melting analysis (HRMA) to detect the SETBP1 mutations in a cohort of 363 patients with...

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Source

Identifiers

PMID: 29549983
DOI: 10.1016/j.prp.2018.03.010

Genes

SETBP1
SRSF2

Provenance

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SETBP1 mutations in Chinese patients with acute myeloid leukemia and myelodysplastic syndrome.PMID 29549983Read ↗

SETBP1 mutation analysis in 944 patients with MDS and AMLSemantic proximity Read ↗

Clinical implications of the SETBP1 mutation in patients with primary myelodysplastic syndrome and its stability during disease progression.Semantic proximity Read ↗

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Detection of SRSF2-P95 mutation by high-resolution melting curve analysis and its effect on prognosis in myelodysplastic syndrome.Semantic proximity Read ↗

SETBP1 mutations as a biomarker for myelodysplasia /myeloproliferative neoplasm overlap syndromeSemantic proximity Read ↗

The impact of SETBP1 mutations in neurological diseases and cancer.Semantic proximity Read ↗

Exploration of the role of gene mutations in myelodysplastic syndromes through a sequencing design involving a small number of target genes.Semantic proximity Read ↗

Differential U2AF1 mutation sites, burden and co-mutation genes can predict prognosis in patients with myelodysplastic syndrome.Semantic proximity Read ↗

SETBP1 mutations occur in 9% of MDS/MPN and in 4% of MPN cases and are strongly associated with atypical CML, monosomy 7, isochromosome i(17)(q10), ASXL1 and CBL mutations.Semantic proximity Read ↗

Identification of a novel de novo mutation of SETBP1 and new findings of SETBP1 in tumorgenesis.Semantic proximity Read ↗

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SETBP1 mutations drive leukemic transformation in ASXL1-mutated MDS.Semantic proximity Read ↗

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