Article
The prognostic implication of SRSF2 mutations in Chinese patients with acute myeloid leukemia.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Aug 2016
Yang Jing, Yao Dong-Ming, Ma Ji-Chun, Yang Lei, Guo Hong, Wen Xiang-Mei, Xiao Gao-Fei, Qian Zhen, Lin Jiang, Qian Jun
Abstract excerpt
Recently, somatic mutations in SRSF2 gene have been discovered in a proportion of hematologic malignancies including acute myeloid leukemia (AML). This study was aimed to investigate SRSF2 mutations in Chinese AML patients. High-resolution melting analysis (HRMA) was developed to screen SRSF2 mutations in 249 cases with AML, and then direct DNA sequencing was used to verify the results of HRMA. In this study,...
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