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Article

Relative tolerance of an enzymatic molten globule and its thermostable counterpart to point mutation.

Biochemistry - 23 Dec 2008

Woycechowsky Kenneth J, Choutko Alexandra, Vamvaca Katherina, Hilvert Donald

Abstract excerpt

Enzyme structures reflect the complex interplay between the free energy of unfolding (DeltaG) and catalytic efficiency. Consequently, the effects of point mutations on structure, stability, and function are difficult to predict. It has been proposed that the mutational robustness of homologous enzymes correlates with a higher initial DeltaG. To examine this issue, we compared the tolerance of a natural...

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Identifiers

PMID: 19053245
DOI: 10.1021/bi801108a

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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