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Article

Connectivity of corticostriatal circuits in nonmanifesting LRRK2 G2385R and R1628P carriers.

CNS neuroscience & therapeutics - 1 Dec 2022

Zhang Dongling, Yao Junye, Ma Jinghong, Gao Linlin, Sun Junyan, Fang Jiliang, He Hongjian, Wu Tao

Abstract excerpt

BACKGROUND: Neuroimaging studies have shown that the functional connectivity (FC) of corticostriatal circuits in nonmanifesting leucine-rich repeat kinase 2 (LRRK2) G2019S mutation carriers mirrors neural changes in idiopathic Parkinson's disease (PD). In contrast, neural network changes in LRRK2 G2385R and R1628P mutations are unclear. We aimed to investigate the FC of corticostriatal circuits in nonmanifesting...

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PMID: 35934920
DOI: 10.1111/cns.13933
PMCID: PMC9627388

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