Article
The translation initiation complex eIF3 in trypanosomatids and other pathogenic excavates--identification of conserved and divergent features based on orthologue analysis.
BMC genomics - 23 Dec 2014
Rezende Antonio M, Assis Ludmila A, Nunes Eduardo C, da Costa Lima Tamara D, Marchini Fabricio K, Freire Eden R, Reis Christian R S, de Melo Neto Osvaldo P
Abstract excerpt
BACKGROUND: The initiation of translation in eukaryotes is supported by the action of several eukaryotic Initiation Factors (eIFs). The largest of these is eIF3, comprising of up to thirteen polypeptides (eIF3a through eIF3m), involved in multiple stages of the initiation process. eIF3 has been better characterized from model organisms, but is poorly known from more diverged groups, including unicellular lineages...
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