Article

Structural differences in translation initiation between pathogenic trypanosomatids and their mammalian hosts

2019-10-16

Abstract excerpt

<h4>SUMMARY</h4> Canonical mRNA translation in eukaryotes begins with the formation of the 43S pre-initiation complex (PIC). Its assembly requires the binding of several eukaryotic initiation factors (eIF 1, 1A, 2, 3 and 5), Met-tRNA i Met and the small ribosomal subunit (40S). Compared to their mammalian hosts, trypanosomatids present significant structural differences in their 40S suggesting substantial variab...

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Literature Corpus work: 2384d68b-8cfc-585a-9173-f9fb8d9c9a2c
DOI: 10.1101/806141

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