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Article

Translation initiation factor eIF1.2 promotes Toxoplasma stage conversion by regulating levels of key differentiation factors.

Nature communications - 23 May 2024

Wang Fengrong, Holmes Michael J, Hong Hea Jin, Thaprawat Pariyamon, Kannan Geetha, Huynh My-Hang, Schultz Tracey L, Licon M Haley, Lourido Sebastian, Dong Wenzhao, Brito Querido Jailson, Sullivan William J, O'Leary Seán E, Carruthers Vern B

Abstract excerpt

The parasite Toxoplasma gondii persists in its hosts by converting from replicating tachyzoites to latent bradyzoites housed in tissue cysts. The molecular mechanisms that mediate T. gondii differentiation remain poorly understood. Through a mutagenesis screen, we identified translation initiation factor eIF1.2 as a critical factor for T. gondii differentiation. A F97L mutation in eIF1.2 or the genetic ablation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38782906
DOI: 10.1038/s41467-024-48685-4
PMCID: PMC11116398

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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