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Structural Differences in Translation Initiation between Pathogenic Trypanosomatids and Their Mammalian Hosts

1 Dec 2020

Abstract excerpt

Canonical mRNA translation in eukaryotes begins with the formation of the 43S pre-initiation complex (PIC). Its assembly requires binding of initiator Met-tRNA i Met and several eukaryotic initiation factors (eIFs) to the small ribosomal subunit (40S). Compared to their mammalian hosts, trypanosomatids present significant structural differences in their 40S, suggesting substantial variability in translation...

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PMID: 33357443
DOI: 10.1016/j.celrep.2020.108534

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