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Evolutionary Conservation and Diversification of the Translation Initiation Apparatus in Trypanosomatids

1 Jan 2012

Abstract excerpt

Trypanosomatids are ancient eukaryotic parasites that migrate between insect vectors and mammalian hosts, causing a range of diseases in humans and domestic animals. Trypanosomatids feature a multitude of unusual molecular features, including polycistronic transcription and subsequent processing by trans-splicing and polyadenylation. Regulation of protein coding genes is posttranscriptional and thus, translation...

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PMID: 22829751
DOI: 10.1155/2012/813718

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