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Heterogeneity of <i>PIK3CA</i> mutational status at the single cell level in circulating tumor cells from metastatic breast cancer patients

9 Dec 2014

Abstract excerpt

Circulating Tumor Cells (CTCs) represent a "liquid biopsy of the tumor" which might allow real-time monitoring of cancer biology and therapies in individual patients. CTCs are extremely rare in the blood stream and their analysis is technically challenging. The CellSearch(®) system provides the enumeration of CTCs with prognostic significance in patients with metastatic breast cancer (mBC), but it does not allow...

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PMID: 25539732
DOI: 10.1016/j.molonc.2014.12.001

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