Article
Single cell mutational analysis of PIK3CA in circulating tumor cells and metastases in breast cancer reveals heterogeneity, discordance, and mutation persistence in cultured disseminated tumor cells from bone marrow.
BMC cancer - 19 Jun 2014
Deng Glenn, Krishnakumar Sujatha, Powell Ashley A, Zhang Haiyu, Mindrinos Michael N, Telli Melinda L, Davis Ronald W, Jeffrey Stefanie S
Abstract excerpt
BACKGROUND: Therapeutic decisions in cancer are generally guided by molecular biomarkers or, for some newer therapeutics, primary tumor genotype. However, because biomarkers or genotypes may change as new metastases emerge, circulating tumor cells (CTCs) from blood are being investigated for a role in guiding real-time drug selection during disease progression, expecting that CTCs will comprehensively represent...
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