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Article

Analysing the mutational status of PIK3CA in circulating tumor cells from metastatic breast cancer patients.

Molecular oncology - 1 Oct 2013

Schneck Helen, Blassl Christina, Meier-Stiegen Franziska, Neves Rui Pedro, Janni Wolfgang, Fehm Tanja, Neubauer Hans

Abstract excerpt

The frequently altered phosphatidylinositol-3-kinase (PI3K)/Akt signaling pathway is involved in the regulation of cellular processes required for breast carcinogenesis. The aim of the project was to develop a method to identify hotspot mutations in the PIK3CA gene in circulating tumor cells (CTCs) of metastatic breast cancer (metBC) patients. From 44 enrolled CTC-positive metBC patients a total number of 57...

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Source

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Identifiers

PMID: 23895914
DOI: 10.1016/j.molonc.2013.07.007
PMCID: PMC5528457

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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